Maybe. More of a noise rather than something you can feel. Mine was really bad after doing a 4 inch lift (that supposedly came with all parts to keep caster and pinion angle balanced), but only occurred when decelerating. It happened at all speeds but was much more noticeable at highway speeds. And I even have the DC style drive shaft. As soon as I removed the front drive shaft it was gone. The lift installer which is a good friend looked it over really well when I took it back. He really felt it was more of a pinion bearing problem that was accentuated with the new pinion angle from the lift. Regardless, I just noticed about a month ago, maybe 10k since the lift that the vibration can't be heard at all. This could be due to new wear angles, or all the heavy shit I've put on the front of the rig, or even coil spring sagging. Either way, mine seems to have went away. I'm also getting new pinion bearings with my gears this week, so I'll really know for sure. My worn out BFG MTs are still a little loud, so............once I get my new tires, if the noise is for some reason still there, I'll know it's the drive shaft, but I'll just live with it for now, no play in the joints. FYI, my caster is about 6, so that would actually improve my pinion angle compared to trying to get a little less caster in the front end.
EDIT: If I were you, I would pull the drive shaft anyway just to see.