Does the superchips really make a difference in fuel mileage?
In a nutshell, no it doesn't, it does help in keeping the tire size to gear ratio correct to keep the canbus/pcm/ecu happy.
The tuning options = adjusting the timing to get a better burn from the fuel you chose to burn (87-93 octane), it helps smooth out the idle and provide a smoother acceleration.
If your gearing is set for your tire size and you're running a performance ignition coil and wires you may see some better mileage but just gearing properly you'll see mileage gains return.
I have a 2010, 4.88 gears and using superchips performance tune, Screamin’ Demon Coil and wires running stock plugs gapped wider, when I had the 315's (35) on I was getting 16-17 around town if I didn't put my foot in it. well, I do have a heavy foot so I actually got 14-15 in town, on the freeway I can get 16-21 depending on the wind and my speed.
I now have 37's and my mileage around town is 13 and on the freeway it's 15, I did manage a stretch at 18mpg but that was with a full tank of ethanol free gas. there is a big difference in performance from the stock tune to the performance tune. When I run ethanol free gas the power and mileage is very noticeable.