Admittedly, my information is likely dated as I have never built or deeply researched LS and LT type engines. My knowledge is informed on more ancient technology (i.e., Gen 1 and 2 engines). On these earlier engines, to make big power you had to sacrifice low-end torque for top-end horsepower (e.g,. higher duration numbers and greater degrees of overlap at low rpm to bleed off cylinder pressure that is then retained as valve events speed up as RPM increases). All of this, of course, is relative to engine displacement.
I would assume the primary factor of consideration is reliability followed closely by your power goal. I would think that your engine would both live longer (i.e., be more reliable) and hit your power goals easier with a supercharger versus building the engine alone to a higher specification. This seems to be the model that GM follows on these engines (e.g., naturally aspirated up to around 500HP and rely on power-adders for anything above that mark).